Jemma Anne Simmons is an English-born former S.H.I.E.L.D. agent and scientist. A genius biochemist, she is one of the youngest and most prominent members of S.H.I.E.L.D.’s research division, along with her partner and husband, Leo Fitz. She, along with Fitz were recruited to Coulson's Team and worked with them on all of their missions. While on the team, Simmons became friends with teammates Skye and Grant Ward. During the HYDRA Uprising, Simmons was an active participant in hunting for John Garrett and the rest of the Centipede Project. She was shocked and saddened to learn that Ward had been a member of HYDRA. Despite the events surrounding the Battle at Cybertek and Fitz's severe injury, Simmons stayed with the team to help rebuild S.H.I.E.L.D. as Nick Fury requested.