Arthur Weasley owned a Ford Anglia 105E that he subsequently enchanted; consequently, the vehicle can fly, become invisible, and carry the entire Weasley family in spite of its formerly non-enchanted interior dimensions (also the Undetectable Extension Charm), among other abilities. In Harry Potter and the Chamber of Secrets, the car is borrowed by Fred, George and Ron, who use it to rescue Harry from the Dursleys' house. Ron and Harry later steal the car in order to return to Hogwarts after the gate to Platform 9¾ is sealed by Dobby. After they arrive at school, landing in the Whomping Willow, the car ejects Harry, Ron, and their luggage, then flees into the Forbidden Forest, ignoring Ron's pleas for it to come back. Mr Weasley soon faces an inquiry at the Ministry of Magic, as seven Muggles saw the car flying across the countryside, and is forced to pay a large fine.

The car reappears when Harry and Ron visit Aragog in the forest: when the great spider's colony of acromantula attempt to devour Harry and Ron, the car attacks the spiders and carries the boys to safety. The car does not return to the Weasleys despite saving Ron and Harry, choosing instead to remain on its own. The car's current condition is undisclosed; Ron had commented that the enchanted vehicle had become "wild" and thus operated autonomously, like a wild animal. In theory, it might still exist when the characters' children attend Hogwarts.

The 1962 Ford Anglia used in the film was acquired by Rupert Grint, who plays Ron Weasley, and is currently displayed in the National Motor Museum, Beaulieu. A total of 14 Ford Anglias were destroyed during the filming of the scene where the car crashes into the Whomping Willow.

A replica of the car in its feral state can be seen in the queue line for the Dragon Challenge roller coaster at Universal Studios Islands of Adventure theme park. Occasionally it blinks its headlights and honks its horn when its motion detectors sense that guests are standing in front of it or walking by it.