Lucille Bluth (née Lucille Jenkins) is the wife of George Bluth, mother of G.O.B., Michael, Lindsay, Buster, and Annyong Bluth, and grandmother of George Michael, Maeby and Steve Holt. She is also mother-in-law to both Tobias Fünke and the deceased Tracey Bluth. She may have a sister, as in "Justice is Blind," Buster Bluth comments that George Sr. brought home a black statue with an erect penis, which remained in the room until "his aunt disapproved." The Bluth family as we know it began when George met and impregnated Lucille, who was working at a Stuckeys.

She is an alcoholic, rarely being seen without a drink in her hand, and spends a short time in rehab. It has been suggested, by her husband, that she is responsible for the family company's morally suspect endeavors. Lucille lives at Balboa Towers with her son Buster, whom she has coddled into a neurotic mess.

Lucille is primarily portrayed by Jessica Walter and has appeared in 66 episodes of Arrested Development. A young version of Lucille is portrayed by Kristen Wiig for seven episodes of Season Four. Lucille was last heard giving G.O.B. control of the Bluth Company on the phone after Lucille 2's disappearance in "Blockheads".