Grimmjow Jaegerjaquez (グリムジョー・ジャガージャック Gurimujō Jagājakku?, romanized as Grimmjow Jaegerjaques in some Japanese media) is the Sexta Espada, signified by the "6" tattooed to his back. His name comes from European architect Nicholas Grimshaw[7] and the German word for hunter. Grimmjow has a defiant, punk attitude towards authority, and can be cowed only by Sōsuke Aizen. Despite his personality, Grimmjow has a sense of honor, repays those he feels he owes a debt to, and is not willing to battle handicapped opponents.[50] Both as an Espada and before his arrancar transformation, Grimmjow leads a close-knit gang of other hollows and dreams of becoming a hollow king himself. Grimmjow dresses in a vest over bare skin and loose pants, and sports blue hair in a style popularized by Billy Idol. A still-articulated right jawbone is all that remains of Grimmjow's hollow mask, and his hollow hole is located on his abdomen.

The aspect of death Grimmjow represents is destruction, a trait he embodies through his savage combat style and violent lust for battle. Grimmjow is a skilled fighter, able to temporarily imprison the more powerful Ulquiorra in his Caja de Negación by exploiting surprise.[51] When his Zanpakutō Pantera (豹王（パンテラ）?, Spanish for "Panther," kanji translates as "Panther King") is released he gains the physical traits of a panther, with prominent jagged teeth, feline ears, clawed hands and feet, an armored hide, and a tail that can be used as a powerful whip.[52] His released state augments his speed and power, allows him to fire destructive darts from his elbows, and protrude immense energy claws called Desgarrón (豹王の爪（デスガロン） Desugaron?, Spanish for "Laceration," kanji translates as "Panther King's Claw") that end at his fingertips. Grimmjow can use the most powerful Cero variety out of any Espada, the Gran Rey Cero (王虚の閃光 (グラン・レイ・セロ) Guran Rei Sero?, Spanish for "Grand King Zero", kanji translates as "Royal Hollow Flash"); Grimmjow and Ulquiorra claim that all Espadas can use it, but only Grimmjow did in the original manga and anime. This Cero variant is banned in Las Noches because it might threaten to destroy the palace.

Grimmjow enters the story early in the Arrancar Arc, the third Espada shown but the first to be introduced as such. He and his five fracciónes impulsively attack Ichigo Kurosaki's hometown after learning of Ichigo's power, but are defeated by the Soul Reapers stationed there, with only Grimmjow returning alive after an aborted battle with Ichigo. He is demoted and maimed for this insolence and failure, but is later healed by Orihime Inoue, and regains his rank immediately by murdering his replacement, Luppi Antenor. After his initial battle with Ichigo Kurosaki, the pair form a competitive rivalry, and he and Ichigo battle several more times, driving each other to grow stronger, until Grimmjow is decisively defeated by Ichigo in Hueco Mundo. Grimmjow survives this defeat, as well as the later Quincy invasion of Hueco Mundo, and becomes a tentative ally of the protagonists.