Dune is a science fiction media franchise that originated with the 1965 novel Dune by Frank Herbert. Dune is frequently cited as the best-selling science fiction novel in history. It won the 1966 Hugo Award and the inaugural Nebula Award for Best Novel, and was later adapted into a 1984 film and a 2000 television miniseries. Herbert wrote five sequels, and the first two were presented as a miniseries in 2003. The Dune universe has also inspired some traditional games and a series of video games. Since 2009, the names of planets from the Dune novels have been adopted for the real-world nomenclature of plains and other features on Saturn's moon Titan.

Frank Herbert died in 1986. Beginning in 1999, his son Brian Herbert and science fiction author Kevin J. Anderson published a number of prequel novels, as well as two which complete the original Dune series (Hunters of Dune in 2006 and Sandworms of Dune in 2007), partially based on Frank Herbert's notes discovered a decade after his death.

The political, scientific, and social fictional setting of Herbert's novels and derivative works is known as the Dune universe, or Duniverse. Set tens of thousands of years in the future, the saga chronicles a civilization which has banned artificial intelligence but has also developed advanced technology and mental and physical abilities. Vital to this empire is the harsh desert planet Arrakis, only known source of the spice melange, the most valuable substance in the universe.

Due to the similarities between some of Herbert's terms and ideas and actual words and concepts in the Arabic language—as well as the series' "Islamic undertones" and themes—a Middle Eastern influence on Herbert's works has been noted repeatedly.